Submitted by aii2002 on October 4, 2019 - 2:39pm
Title | cAMP and mitochondria. |
Publication Type | Journal Article |
Year of Publication | 2013 |
Authors | Valsecchi F, Ramos-Espiritu LS, Buck J, Levin LR, Manfredi G |
Journal | Physiology (Bethesda) |
Volume | 28 |
Issue | 3 |
Pagination | 199-209 |
Date Published | 2013 May |
ISSN | 1548-9221 |
Keywords | Adenylyl Cyclases, Animals, Cyclic AMP, Cyclic AMP-Dependent Protein Kinases, Energy Metabolism, Humans, Mitochondria, Mitochondrial Proteins, Phosphorylation, Second Messenger Systems |
Abstract | Phosphorylation of mitochondrial proteins has emerged as a major regulatory mechanism for metabolic adaptation. cAMP signaling and PKA phosphorylation of mitochondrial proteins have just started to be investigated, and the presence of cAMP-generating enzymes and PKA inside mitochondria is still controversial. Here, we discuss the role of cAMP in regulating mitochondrial bioenergetics through protein phosphorylation and the evidence for soluble adenylyl cyclase as the source of cAMP inside mitochondria. |
DOI | 10.1152/physiol.00004.2013 |
Alternate Journal | Physiology (Bethesda) |
PubMed ID | 23636265 |
PubMed Central ID | PMC3870303 |
Grant List | R01 GM062328 / GM / NIGMS NIH HHS / United States GM-088999 / GM / NIGMS NIH HHS / United States R01 NS055255 / NS / NINDS NIH HHS / United States GM-62328 / GM / NIGMS NIH HHS / United States R01 HD059913 / HD / NICHD NIH HHS / United States R01 GM088999 / GM / NIGMS NIH HHS / United States NS-55255 / NS / NINDS NIH HHS / United States HD-059913 / HD / NICHD NIH HHS / United States |