cAMP and mitochondria.

TitlecAMP and mitochondria.
Publication TypeJournal Article
Year of Publication2013
AuthorsValsecchi F, Ramos-Espiritu LS, Buck J, Levin LR, Manfredi G
JournalPhysiology (Bethesda)
Volume28
Issue3
Pagination199-209
Date Published2013 May
ISSN1548-9221
KeywordsAdenylyl Cyclases, Animals, Cyclic AMP, Cyclic AMP-Dependent Protein Kinases, Energy Metabolism, Humans, Mitochondria, Mitochondrial Proteins, Phosphorylation, Second Messenger Systems
Abstract

Phosphorylation of mitochondrial proteins has emerged as a major regulatory mechanism for metabolic adaptation. cAMP signaling and PKA phosphorylation of mitochondrial proteins have just started to be investigated, and the presence of cAMP-generating enzymes and PKA inside mitochondria is still controversial. Here, we discuss the role of cAMP in regulating mitochondrial bioenergetics through protein phosphorylation and the evidence for soluble adenylyl cyclase as the source of cAMP inside mitochondria.

DOI10.1152/physiol.00004.2013
Alternate JournalPhysiology (Bethesda)
PubMed ID23636265
PubMed Central IDPMC3870303
Grant ListR01 GM062328 / GM / NIGMS NIH HHS / United States
GM-088999 / GM / NIGMS NIH HHS / United States
R01 NS055255 / NS / NINDS NIH HHS / United States
GM-62328 / GM / NIGMS NIH HHS / United States
R01 HD059913 / HD / NICHD NIH HHS / United States
R01 GM088999 / GM / NIGMS NIH HHS / United States
NS-55255 / NS / NINDS NIH HHS / United States
HD-059913 / HD / NICHD NIH HHS / United States