Publications

Rossetti T, Ferreira J, Ghanem L, Buck H, Steegborn C, Myers RW, Meinke PT, Levin LR, Buck J.  2022.  Assessing potency and binding kinetics of soluble adenylyl cyclase (sAC) inhibitors to maximize therapeutic potential.. Front Physiol. 13:1013845.

Miller M, Rossetti T, Ferreira J, Ghanem L, Balbach M, Kaur N, Levin LR, Buck J, Kehr M, Coquille S et al..  2022.  Design, Synthesis, and Pharmacological Evaluation of Second-Generation Soluble Adenylyl Cyclase (sAC, ADCY10) Inhibitors with Slow Dissociation Rates.. J Med Chem. 65(22):15208-15226.

Ferreira J, Levin LR, Buck J.  2022.  Strategies to safely target widely expressed soluble adenylyl cyclase for contraception.. Front Pharmacol. 13:953903.

Rossetti T, Jackvony S, Buck J, Levin LR.  2021.  Bicarbonate, carbon dioxide and pH sensing via mammalian bicarbonate-regulated soluble adenylyl cyclase.. Interface Focus. 11(2):20200034.

Fushimi M, Buck H, Balbach M, Gorovyy A, Ferreira J, Rossetti T, Kaur N, Levin LR, Buck J, Quast J et al..  2021.  Discovery of TDI-10229: A Potent and Orally Bioavailable Inhibitor of Soluble Adenylyl Cyclase (sAC, ADCY10).. ACS Med Chem Lett. 12(8):1283-1287.

Balbach M, Ghanem L, Rossetti T, Kaur N, Ritagliati C, Ferreira J, Krapf D, Molina LCPuga, Santi CMaria, Hansen JNiklas et al..  2021.  Soluble adenylyl cyclase inhibition prevents human sperm functions essential for fertilization.. Mol Hum Reprod. 27(9)

Chang J-C, Go S, Gilglioni EH, Duijst S, Panneman DM, Rodenburg RJ, Li HLam, Huang H-L, Levin LR, Buck J et al..  2021.  Soluble adenylyl cyclase regulates the cytosolic NADH/NAD+ redox state and the bioenergetic switch between glycolysis and oxidative phosphorylation.. Biochim Biophys Acta Bioenerg. 1862(4):148367.

Hidalgo DM, Romarowski A, Gervasi MG, Navarrete F, Balbach M, Salicioni AM, Levin LR, Buck J, Visconti PE.  2020.  Capacitation increases glucose consumption in murine sperm.. Mol Reprod Dev.

Wang X, Cai B, Yang X, Sonubi OO, Zheng Z, Ramakrishnan R, Shi H, Valenti L, Pajvani UB, Sandhu J et al..  2020.  Cholesterol Stabilizes TAZ in Hepatocytes to Promote Experimental Non-alcoholic Steatohepatitis.. Cell Metab. 31(5):969-986.e7.

Balbach M, Gervasi MGracia, Hidalgo DMartin, Visconti PE, Levin LR, Buck J.  2020.  Metabolic changes in mouse sperm during capacitation†.. Biol Reprod. 103(4):791-801.

Balbach M, Fushimi M, Huggins DJ, Steegborn C, Meinke PT, Levin LR, Buck J.  2020.  Optimization of lead compounds into on-demand, nonhormonal contraceptives: leveraging a public-private drug discovery institute collaboration†.. Biol Reprod. 103(2):176-182.

Balbach M, Buck J, Levin LR.  2020.  Using an Extracellular Flux Analyzer to Measure Changes in Glycolysis and Oxidative Phosphorylation during Mouse Sperm Capacitation.. J Vis Exp. (155)

Navarrete FA, Aguila L, Martin-Hidalgo D, Tourzani DA, Luque GM, Ardestani G, Garcia-Vazquez FA, Levin LR, Buck J, Darszon A et al..  2019.  Transient Sperm Starvation Improves the Outcome of Assisted Reproductive Technologies.. Front Cell Dev Biol. 7:262.

Zhou D, Ota K, Nardin C, Feldman M, Widman A, Wind O, Simon A, Reilly M, Levin LR, Buck J et al..  2018.  Mammalian pigmentation is regulated by a distinct cAMP-dependent mechanism that controls melanosome pH.. Sci Signal. 11(555)

Wiggins SV, Steegborn C, Levin LR, Buck J.  2018.  Pharmacological modulation of the CO/HCO/pH-, calcium-, and ATP-sensing soluble adenylyl cyclase.. Pharmacol Ther. 190:173-186.

Gandhi JK, Chowdhury URoy, Manzar Z, Buck J, Levin LR, Fautsch MP, Marmorstein AD.  2017.  Differential Intraocular Pressure Measurements by Tonometry and Direct Cannulation After Treatment with Soluble Adenylyl Cyclase Inhibitors.. J Ocul Pharmacol Ther. 33(8):574-581.

Valsecchi F, Konrad C, D'Aurelio M, Ramos-Espiritu LS, Stepanova A, Burstein SR, Galkin A, Magranè J, Starkov A, Buck J et al..  2017.  Distinct intracellular sAC-cAMP domains regulate ER Ca signaling and OXPHOS function.. J Cell Sci. 130(21):3713-3727.

Kleinboelting S, Ramos-Espiritu L, Buck H, Colis L, van den Heuvel J, J Glickman F, Levin LR, Buck J, Steegborn C.  2016.  Bithionol Potently Inhibits Human Soluble Adenylyl Cyclase through Binding to the Allosteric Activator Site.. J Biol Chem. 291(18):9776-84.

Ramos-Espiritu L, Kleinboelting S, Navarrete FA, Alvau A, Visconti PE, Valsecchi F, Starkov A, Manfredi G, Buck H, Adura C et al..  2016.  Discovery of LRE1 as a specific and allosteric inhibitor of soluble adenylyl cyclase.. Nat Chem Biol. 12(10):838-44.

Ramos-Espiritu L, Diaz A, Nardin C, Saviola AJ, Shaw F, Plitt T, Yang X, Wolchok J, Pirog EC, Desman G et al..  2016.  The metabolic/pH sensor soluble adenylyl cyclase is a tumor suppressor protein.. Oncotarget. 7(29):45597-45607.

Rahman N, Ramos-Espiritu L, Milner TA, Buck J, Levin LR.  2016.  Soluble adenylyl cyclase is essential for proper lysosomal acidification.. J Gen Physiol. 148(4):325-39.

Navarrete FA, Alvau A, Lee HChang, Levin LR, Buck J, De Leon PMartin-, Santi CM, Krapf D, Mager J, Fissore RA et al..  2016.  Transient exposure to calcium ionophore enables in vitro fertilization in sterile mouse models.. Sci Rep. 6:33589.

Watson RL, Buck J, Levin LR, Winger RC, Wang J, Arase H, Muller WA.  2015.  Endothelial CD99 signals through soluble adenylyl cyclase and PKA to regulate leukocyte transendothelial migration.. J Exp Med. 212(7):1021-41.

Levin LR, Buck J.  2015.  Physiological roles of acid-base sensors.. Annu Rev Physiol. 77:347-62.

Kleinboelting S, Diaz A, Moniot S, van den Heuvel J, Weyand M, Levin LR, Buck J, Steegborn C.  2014.  Crystal structures of human soluble adenylyl cyclase reveal mechanisms of catalysis and of its activation through bicarbonate.. Proc Natl Acad Sci U S A. 111(10):3727-32.