Submitted by aii2002 on October 4, 2019 - 2:34pm
Title | Physiological roles of acid-base sensors. |
Publication Type | Journal Article |
Year of Publication | 2015 |
Authors | Levin LR, Buck J |
Journal | Annu Rev Physiol |
Volume | 77 |
Pagination | 347-62 |
Date Published | 2015 |
ISSN | 1545-1585 |
Keywords | Acid Sensing Ion Channels, Acid-Base Equilibrium, Acid-Base Imbalance, Adenylyl Cyclases, Animals, Bicarbonates, Carbon Dioxide, Homeostasis, Humans, Hydrogen-Ion Concentration, Protons |
Abstract | Acid-base homeostasis is essential for life. The macromolecules upon which living organisms depend are sensitive to pH changes, and physiological systems use the equilibrium between carbon dioxide, bicarbonate, and protons to buffer their pH. Biological processes and environmental insults are constantly challenging an organism's pH; therefore, to maintain a consistent and proper pH, organisms need sensors that measure pH and that elicit appropriate responses. Mammals use multiple sensors for measuring both intracellular and extracellular pH, and although some mammalian pH sensors directly measure protons, it has recently become apparent that many pH-sensing systems measure pH via bicarbonate-sensing soluble adenylyl cyclase. |
DOI | 10.1146/annurev-physiol-021014-071821 |
Alternate Journal | Annu. Rev. Physiol. |
PubMed ID | 25340964 |
Grant List | GM62328 / GM / NIGMS NIH HHS / United States HD059913 / HD / NICHD NIH HHS / United States |