Submitted by jaf4002 on February 14, 2023 - 3:11pm
| Title | Strategies to safely target widely expressed soluble adenylyl cyclase for contraception. |
| Publication Type | Journal Article |
| Year of Publication | 2022 |
| Authors | Ferreira J, Levin LR, Buck J |
| Journal | Front Pharmacol |
| Volume | 13 |
| Pagination | 953903 |
| Date Published | 2022 |
| ISSN | 1663-9812 |
| Abstract | In humans, the prototypical second messenger cyclic AMP is produced by 10 adenylyl cyclase isoforms, which are divided into two classes. Nine isoforms are G protein coupled transmembrane adenylyl cyclases (tmACs; ADCY1-9) and the 10th is the bicarbonate regulated soluble adenylyl cyclase (sAC; ADCY10). This review details why sAC is uniquely druggable and outlines ways to target sAC for novel forms of male and female contraception. |
| DOI | 10.3389/fphar.2022.953903 |
| Alternate Journal | Front Pharmacol |
| PubMed ID | 36091839 |
| PubMed Central ID | PMC9452739 |
| Grant List | P50 HD100549 / HD / NICHD NIH HHS / United States R01 AG061290 / AG / NIA NIH HHS / United States R01 HD088571 / HD / NICHD NIH HHS / United States |