Publications

Rossetti T, Ferreira J, Ghanem L, Buck H, Steegborn C, Myers RW, Meinke PT, Levin LR, Buck J.  2022.  Assessing potency and binding kinetics of soluble adenylyl cyclase (sAC) inhibitors to maximize therapeutic potential.. Front Physiol. 13:1013845.

Miller M, Rossetti T, Ferreira J, Ghanem L, Balbach M, Kaur N, Levin LR, Buck J, Kehr M, Coquille S et al..  2022.  Design, Synthesis, and Pharmacological Evaluation of Second-Generation Soluble Adenylyl Cyclase (sAC, ADCY10) Inhibitors with Slow Dissociation Rates.. J Med Chem. 65(22):15208-15226.

Fushimi M, Buck H, Balbach M, Gorovyy A, Ferreira J, Rossetti T, Kaur N, Levin LR, Buck J, Quast J et al..  2021.  Discovery of TDI-10229: A Potent and Orally Bioavailable Inhibitor of Soluble Adenylyl Cyclase (sAC, ADCY10).. ACS Med Chem Lett. 12(8):1283-1287.

Balbach M, Fushimi M, Huggins DJ, Steegborn C, Meinke PT, Levin LR, Buck J.  2020.  Optimization of lead compounds into on-demand, nonhormonal contraceptives: leveraging a public-private drug discovery institute collaboration†.. Biol Reprod. 103(2):176-182.

Wiggins SV, Steegborn C, Levin LR, Buck J.  2018.  Pharmacological modulation of the CO/HCO/pH-, calcium-, and ATP-sensing soluble adenylyl cyclase.. Pharmacol Ther. 190:173-186.

Kleinboelting S, Ramos-Espiritu L, Buck H, Colis L, van den Heuvel J, J Glickman F, Levin LR, Buck J, Steegborn C.  2016.  Bithionol Potently Inhibits Human Soluble Adenylyl Cyclase through Binding to the Allosteric Activator Site.. J Biol Chem. 291(18):9776-84.

Ramos-Espiritu L, Kleinboelting S, Navarrete FA, Alvau A, Visconti PE, Valsecchi F, Starkov A, Manfredi G, Buck H, Adura C et al..  2016.  Discovery of LRE1 as a specific and allosteric inhibitor of soluble adenylyl cyclase.. Nat Chem Biol. 12(10):838-44.

Kleinboelting S, Diaz A, Moniot S, van den Heuvel J, Weyand M, Levin LR, Buck J, Steegborn C.  2014.  Crystal structures of human soluble adenylyl cyclase reveal mechanisms of catalysis and of its activation through bicarbonate.. Proc Natl Acad Sci U S A. 111(10):3727-32.

Topal H, Fulcher NB, Bitterman J, Salazar E, Buck J, Levin LR, Cann MJ, Wolfgang MC, Steegborn C.  2012.  Crystal structure and regulation mechanisms of the CyaB adenylyl cyclase from the human pathogen Pseudomonas aeruginosa.. J Mol Biol. 416(2):271-86.

Middelhaufe S, Leipelt M, Levin LR, Buck J, Steegborn C.  2012.  Identification of a haem domain in human soluble adenylate cyclase.. Biosci Rep. 32(5):491-9.