Publications

Rahman N, Ramos-Espiritu L, Milner TA, Buck J, Levin LR.  2016.  Soluble adenylyl cyclase is essential for proper lysosomal acidification.. J Gen Physiol. 148(4):325-39.

Rahman N, Buck J, Levin LR.  2013.  pH sensing via bicarbonate-regulated "soluble" adenylyl cyclase (sAC).. Front Physiol. 4:343.

Ramos-Espiritu L, Diaz A, Nardin C, Saviola AJ, Shaw F, Plitt T, Yang X, Wolchok J, Pirog EC, Desman G et al..  2016.  The metabolic/pH sensor soluble adenylyl cyclase is a tumor suppressor protein.. Oncotarget. 7(29):45597-45607.

Ramos-Espiritu L, Kleinboelting S, Navarrete FA, Alvau A, Visconti PE, Valsecchi F, Starkov A, Manfredi G, Buck H, Adura C et al..  2016.  Discovery of LRE1 as a specific and allosteric inhibitor of soluble adenylyl cyclase.. Nat Chem Biol. 12(10):838-44.

Rossetti T, Jackvony S, Buck J, Levin LR.  2021.  Bicarbonate, carbon dioxide and pH sensing via mammalian bicarbonate-regulated soluble adenylyl cyclase.. Interface Focus. 11(2):20200034.

Rossetti T, Ferreira J, Ghanem L, Buck H, Steegborn C, Myers RW, Meinke PT, Levin LR, Buck J.  2022.  Assessing potency and binding kinetics of soluble adenylyl cyclase (sAC) inhibitors to maximize therapeutic potential.. Front Physiol. 13:1013845.

Salazar E, Bank EM, Ramsey N, Hess KC, Deitsch KW, Levin LR, Buck J.  2012.  Characterization of Plasmodium falciparum adenylyl cyclase-β and its role in erythrocytic stage parasites.. PLoS One. 7(6):e39769.

Shahidullah M, Mandal A, Wei G, Levin LR, Buck J, Delamere NA.  2014.  Nonpigmented ciliary epithelial cells respond to acetazolamide by a soluble adenylyl cyclase mechanism.. Invest Ophthalmol Vis Sci. 55(1):187-97.

Topal H, Fulcher NB, Bitterman J, Salazar E, Buck J, Levin LR, Cann MJ, Wolfgang MC, Steegborn C.  2012.  Crystal structure and regulation mechanisms of the CyaB adenylyl cyclase from the human pathogen Pseudomonas aeruginosa.. J Mol Biol. 416(2):271-86.

Valsecchi F, Konrad C, D'Aurelio M, Ramos-Espiritu LS, Stepanova A, Burstein SR, Galkin A, Magranè J, Starkov A, Buck J et al..  2017.  Distinct intracellular sAC-cAMP domains regulate ER Ca signaling and OXPHOS function.. J Cell Sci. 130(21):3713-3727.

Valsecchi F, Ramos-Espiritu LS, Buck J, Levin LR, Manfredi G.  2013.  cAMP and mitochondria.. Physiology (Bethesda). 28(3):199-209.

Wang X, Cai B, Yang X, Sonubi OO, Zheng Z, Ramakrishnan R, Shi H, Valenti L, Pajvani UB, Sandhu J et al..  2020.  Cholesterol Stabilizes TAZ in Hepatocytes to Promote Experimental Non-alcoholic Steatohepatitis.. Cell Metab. 31(5):969-986.e7.

Watson RL, Buck J, Levin LR, Winger RC, Wang J, Arase H, Muller WA.  2015.  Endothelial CD99 signals through soluble adenylyl cyclase and PKA to regulate leukocyte transendothelial migration.. J Exp Med. 212(7):1021-41.

Wertheimer E, Krapf D, de la Vega-Beltran JL, Sánchez-Cárdenas C, Navarrete F, Haddad D, Escoffier J, Salicioni AM, Levin LR, Buck J et al..  2013.  Compartmentalization of distinct cAMP signaling pathways in mammalian sperm.. J Biol Chem. 288(49):35307-20.

Wiggins SV, Steegborn C, Levin LR, Buck J.  2018.  Pharmacological modulation of the CO/HCO/pH-, calcium-, and ATP-sensing soluble adenylyl cyclase.. Pharmacol Ther. 190:173-186.

Zhou D, Ota K, Nardin C, Feldman M, Widman A, Wind O, Simon A, Reilly M, Levin LR, Buck J et al..  2018.  Mammalian pigmentation is regulated by a distinct cAMP-dependent mechanism that controls melanosome pH.. Sci Signal. 11(555)

Zippin JH, Chen Y, Straub SG, Hess KC, Diaz A, Lee D, Tso P, Holz GG, Sharp GWG, Levin LR et al..  2013.  CO2/HCO3(-)- and calcium-regulated soluble adenylyl cyclase as a physiological ATP sensor.. J Biol Chem. 288(46):33283-91.