Publications

Valsecchi F, Konrad C, D'Aurelio M, Ramos-Espiritu LS, Stepanova A, Burstein SR, Galkin A, Magranè J, Starkov A, Buck J et al..  2017.  Distinct intracellular sAC-cAMP domains regulate ER Ca signaling and OXPHOS function.. J Cell Sci. 130(21):3713-3727.

Fushimi M, Buck H, Balbach M, Gorovyy A, Ferreira J, Rossetti T, Kaur N, Levin LR, Buck J, Quast J et al..  2021.  Discovery of TDI-10229: A Potent and Orally Bioavailable Inhibitor of Soluble Adenylyl Cyclase (sAC, ADCY10).. ACS Med Chem Lett. 12(8):1283-1287.

Ramos-Espiritu L, Kleinboelting S, Navarrete FA, Alvau A, Visconti PE, Valsecchi F, Starkov A, Manfredi G, Buck H, Adura C et al..  2016.  Discovery of LRE1 as a specific and allosteric inhibitor of soluble adenylyl cyclase.. Nat Chem Biol. 12(10):838-44.

Gandhi JK, Chowdhury URoy, Manzar Z, Buck J, Levin LR, Fautsch MP, Marmorstein AD.  2017.  Differential Intraocular Pressure Measurements by Tonometry and Direct Cannulation After Treatment with Soluble Adenylyl Cyclase Inhibitors.. J Ocul Pharmacol Ther. 33(8):574-581.

Miller M, Rossetti T, Ferreira J, Ghanem L, Balbach M, Kaur N, Levin LR, Buck J, Kehr M, Coquille S et al..  2022.  Design, Synthesis, and Pharmacological Evaluation of Second-Generation Soluble Adenylyl Cyclase (sAC, ADCY10) Inhibitors with Slow Dissociation Rates.. J Med Chem. 65(22):15208-15226.

Kleinboelting S, Diaz A, Moniot S, van den Heuvel J, Weyand M, Levin LR, Buck J, Steegborn C.  2014.  Crystal structures of human soluble adenylyl cyclase reveal mechanisms of catalysis and of its activation through bicarbonate.. Proc Natl Acad Sci U S A. 111(10):3727-32.

Topal H, Fulcher NB, Bitterman J, Salazar E, Buck J, Levin LR, Cann MJ, Wolfgang MC, Steegborn C.  2012.  Crystal structure and regulation mechanisms of the CyaB adenylyl cyclase from the human pathogen Pseudomonas aeruginosa.. J Mol Biol. 416(2):271-86.

Wertheimer E, Krapf D, de la Vega-Beltran JL, Sánchez-Cárdenas C, Navarrete F, Haddad D, Escoffier J, Salicioni AM, Levin LR, Buck J et al..  2013.  Compartmentalization of distinct cAMP signaling pathways in mammalian sperm.. J Biol Chem. 288(49):35307-20.

Zippin JH, Chen Y, Straub SG, Hess KC, Diaz A, Lee D, Tso P, Holz GG, Sharp GWG, Levin LR et al..  2013.  CO2/HCO3(-)- and calcium-regulated soluble adenylyl cyclase as a physiological ATP sensor.. J Biol Chem. 288(46):33283-91.

Wang X, Cai B, Yang X, Sonubi OO, Zheng Z, Ramakrishnan R, Shi H, Valenti L, Pajvani UB, Sandhu J et al..  2020.  Cholesterol Stabilizes TAZ in Hepatocytes to Promote Experimental Non-alcoholic Steatohepatitis.. Cell Metab. 31(5):969-986.e7.

Salazar E, Bank EM, Ramsey N, Hess KC, Deitsch KW, Levin LR, Buck J.  2012.  Characterization of Plasmodium falciparum adenylyl cyclase-β and its role in erythrocytic stage parasites.. PLoS One. 7(6):e39769.

Hidalgo DM, Romarowski A, Gervasi MG, Navarrete F, Balbach M, Salicioni AM, Levin LR, Buck J, Visconti PE.  2020.  Capacitation increases glucose consumption in murine sperm.. Mol Reprod Dev.

Valsecchi F, Ramos-Espiritu LS, Buck J, Levin LR, Manfredi G.  2013.  cAMP and mitochondria.. Physiology (Bethesda). 28(3):199-209.

Kleinboelting S, Ramos-Espiritu L, Buck H, Colis L, van den Heuvel J, J Glickman F, Levin LR, Buck J, Steegborn C.  2016.  Bithionol Potently Inhibits Human Soluble Adenylyl Cyclase through Binding to the Allosteric Activator Site.. J Biol Chem. 291(18):9776-84.

Rossetti T, Jackvony S, Buck J, Levin LR.  2021.  Bicarbonate, carbon dioxide and pH sensing via mammalian bicarbonate-regulated soluble adenylyl cyclase.. Interface Focus. 11(2):20200034.

Rossetti T, Ferreira J, Ghanem L, Buck H, Steegborn C, Myers RW, Meinke PT, Levin LR, Buck J.  2022.  Assessing potency and binding kinetics of soluble adenylyl cyclase (sAC) inhibitors to maximize therapeutic potential.. Front Physiol. 13:1013845.

Kolodecik TR, Shugrue CA, Thrower EC, Levin LR, Buck J, Gorelick FS.  2012.  Activation of soluble adenylyl cyclase protects against secretagogue stimulated zymogen activation in rat pancreaic acinar cells.. PLoS One. 7(7):e41320.