Publications

Fushimi M, Buck H, Balbach M, Gorovyy A, Ferreira J, Rossetti T, Kaur N, Levin LR, Buck J, Quast J et al..  2021.  Discovery of TDI-10229: A Potent and Orally Bioavailable Inhibitor of Soluble Adenylyl Cyclase (sAC, ADCY10).. ACS Med Chem Lett. 12(8):1283-1287.

Balbach M, Ghanem L, Rossetti T, Kaur N, Ritagliati C, Ferreira J, Krapf D, Molina LCPuga, Santi CMaria, Hansen JNiklas et al..  2021.  Soluble adenylyl cyclase inhibition prevents human sperm functions essential for fertilization.. Mol Hum Reprod. 27(9)

Rossetti T, Ferreira J, Ghanem L, Buck H, Steegborn C, Myers RW, Meinke PT, Levin LR, Buck J.  2022.  Assessing potency and binding kinetics of soluble adenylyl cyclase (sAC) inhibitors to maximize therapeutic potential.. Front Physiol. 13:1013845.

Miller M, Rossetti T, Ferreira J, Ghanem L, Balbach M, Kaur N, Levin LR, Buck J, Kehr M, Coquille S et al..  2022.  Design, Synthesis, and Pharmacological Evaluation of Second-Generation Soluble Adenylyl Cyclase (sAC, ADCY10) Inhibitors with Slow Dissociation Rates.. J Med Chem. 65(22):15208-15226.

Ferreira J, Levin LR, Buck J.  2022.  Strategies to safely target widely expressed soluble adenylyl cyclase for contraception.. Front Pharmacol. 13:953903.