Publications

Balbach M, Gervasi MGracia, Hidalgo DMartin, Visconti PE, Levin LR, Buck J.  2020.  Metabolic changes in mouse sperm during capacitation†.. Biol Reprod. 103(4):791-801.

Choi HB, Gordon GRJ, Zhou N, Tai C, Rungta RL, Martinez J, Milner TA, Ryu JK, McLarnon JG, Tresguerres M et al..  2012.  Metabolic communication between astrocytes and neurons via bicarbonate-responsive soluble adenylyl cyclase.. Neuron. 75(6):1094-104.

Ramos-Espiritu L, Diaz A, Nardin C, Saviola AJ, Shaw F, Plitt T, Yang X, Wolchok J, Pirog EC, Desman G et al..  2016.  The metabolic/pH sensor soluble adenylyl cyclase is a tumor suppressor protein.. Oncotarget. 7(29):45597-45607.

Hess KC, Liu J, Manfredi G, Mühlschlegel FA, Buck J, Levin LR, Barrientos A.  2014.  A mitochondrial CO2-adenylyl cyclase-cAMP signalosome controls yeast normoxic cytochrome c oxidase activity.. FASEB J. 28(10):4369-80.

Chen J, Martinez J, Milner TA, Buck J, Levin LR.  2013.  Neuronal expression of soluble adenylyl cyclase in the mammalian brain.. Brain Res. 1518:1-8.

Shahidullah M, Mandal A, Wei G, Levin LR, Buck J, Delamere NA.  2014.  Nonpigmented ciliary epithelial cells respond to acetazolamide by a soluble adenylyl cyclase mechanism.. Invest Ophthalmol Vis Sci. 55(1):187-97.

Balbach M, Fushimi M, Huggins DJ, Steegborn C, Meinke PT, Levin LR, Buck J.  2020.  Optimization of lead compounds into on-demand, nonhormonal contraceptives: leveraging a public-private drug discovery institute collaboration†.. Biol Reprod. 103(2):176-182.

Rahman N, Buck J, Levin LR.  2013.  pH sensing via bicarbonate-regulated "soluble" adenylyl cyclase (sAC).. Front Physiol. 4:343.

Bitterman JL, Ramos-Espiritu L, Diaz A, Levin LR, Buck J.  2013.  Pharmacological distinction between soluble and transmembrane adenylyl cyclases.. J Pharmacol Exp Ther. 347(3):589-98.

Wiggins SV, Steegborn C, Levin LR, Buck J.  2018.  Pharmacological modulation of the CO/HCO/pH-, calcium-, and ATP-sensing soluble adenylyl cyclase.. Pharmacol Ther. 190:173-186.

Levin LR, Buck J.  2015.  Physiological roles of acid-base sensors.. Annu Rev Physiol. 77:347-62.

Buck J, Levin LR.  2014.  The role of soluble adenylyl cyclase in health and disease.. Biochim Biophys Acta. 1842(12 Pt B):2533-4.

Chen J, Levin LR, Buck J.  2012.  Role of soluble adenylyl cyclase in the heart.. Am J Physiol Heart Circ Physiol. 302(3):H538-43.

Chen X, Baumlin N, Buck J, Levin LR, Fregien N, Salathe M.  2014.  A soluble adenylyl cyclase form targets to axonemes and rescues beat regulation in soluble adenylyl cyclase knockout mice.. Am J Respir Cell Mol Biol. 51(6):750-60.

Balbach M, Ghanem L, Rossetti T, Kaur N, Ritagliati C, Ferreira J, Krapf D, Molina LCPuga, Santi CMaria, Hansen JNiklas et al..  2021.  Soluble adenylyl cyclase inhibition prevents human sperm functions essential for fertilization.. Mol Hum Reprod. 27(9)

Rahman N, Ramos-Espiritu L, Milner TA, Buck J, Levin LR.  2016.  Soluble adenylyl cyclase is essential for proper lysosomal acidification.. J Gen Physiol. 148(4):325-39.

Martinez J, Stessin AM, Campana A, Hou J, Nikulina E, Buck J, Levin LR, Filbin MT.  2014.  Soluble adenylyl cyclase is necessary and sufficient to overcome the block of axonal growth by myelin-associated factors.. J Neurosci. 34(28):9281-9.

Chang J-C, Go S, Gilglioni EH, Duijst S, Panneman DM, Rodenburg RJ, Li HLam, Huang H-L, Levin LR, Buck J et al..  2021.  Soluble adenylyl cyclase regulates the cytosolic NADH/NAD+ redox state and the bioenergetic switch between glycolysis and oxidative phosphorylation.. Biochim Biophys Acta Bioenerg. 1862(4):148367.

Violante S, Kyaw A, Kouatli L, Paladugu K, Apostolakis L, Jenks M, Johnson A, Sheldon RD, Whitten D, Schilmiller AL et al..  2025.  Sperm meet the elevated energy demands to attain fertilization competence by increasing flux through aldolase.. Proc Natl Acad Sci U S A. 122(39):e2506417122.

Ferreira J, Levin LR, Buck J.  2022.  Strategies to safely target widely expressed soluble adenylyl cyclase for contraception.. Front Pharmacol. 13:953903.

Ritagliati C, Devine F, Buck J, Levin LR.  2026.  Sustained soluble adenylyl cyclase (sAC)-generated cAMP is necessary and sufficient for hyperactivated motility in human sperm.. Hum Reprod. 41(2):185-194.

Gardner ER, Kopf GS, Buck J, Levin LR.  2026.  Targeting Soluble Adenylyl Cyclase for On-Demand Contraception.. Physiology (Bethesda). 41(5)

Navarrete FA, Alvau A, Lee HChang, Levin LR, Buck J, De Leon PMartin-, Santi CM, Krapf D, Mager J, Fissore RA et al..  2016.  Transient exposure to calcium ionophore enables in vitro fertilization in sterile mouse models.. Sci Rep. 6:33589.

Navarrete FA, Aguila L, Martin-Hidalgo D, Tourzani DA, Luque GM, Ardestani G, Garcia-Vazquez FA, Levin LR, Buck J, Darszon A et al..  2019.  Transient Sperm Starvation Improves the Outcome of Assisted Reproductive Technologies.. Front Cell Dev Biol. 7:262.

Balbach M, Buck J, Levin LR.  2020.  Using an Extracellular Flux Analyzer to Measure Changes in Glycolysis and Oxidative Phosphorylation during Mouse Sperm Capacitation.. J Vis Exp. (155)