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Publications
Found 42 results
Author
Title
Type
Year
2017
Gandhi JK
,
Chowdhury URoy
,
Manzar Z
,
Buck J
,
Levin LR
,
Fautsch MP
,
Marmorstein AD
. 2017.
Differential Intraocular Pressure Measurements by Tonometry and Direct Cannulation After Treatment with Soluble Adenylyl Cyclase Inhibitors.
.
J Ocul Pharmacol Ther. 33(8):574-581.
Valsecchi F
,
Konrad C
,
D'Aurelio M
,
Ramos-Espiritu LS
,
Stepanova A
,
Burstein SR
,
Galkin A
,
Magranè J
,
Starkov A
,
Buck J
et al.
. 2017.
Distinct intracellular sAC-cAMP domains regulate ER Ca signaling and OXPHOS function.
.
J Cell Sci. 130(21):3713-3727.
2018
Zhou D
,
Ota K
,
Nardin C
,
Feldman M
,
Widman A
,
Wind O
,
Simon A
,
Reilly M
,
Levin LR
,
Buck J
et al.
. 2018.
Mammalian pigmentation is regulated by a distinct cAMP-dependent mechanism that controls melanosome pH.
.
Sci Signal. 11(555)
Wiggins SV
,
Steegborn C
,
Levin LR
,
Buck J
. 2018.
Pharmacological modulation of the CO/HCO/pH-, calcium-, and ATP-sensing soluble adenylyl cyclase.
.
Pharmacol Ther. 190:173-186.
2019
Navarrete FA
,
Aguila L
,
Martin-Hidalgo D
,
Tourzani DA
,
Luque GM
,
Ardestani G
,
Garcia-Vazquez FA
,
Levin LR
,
Buck J
,
Darszon A
et al.
. 2019.
Transient Sperm Starvation Improves the Outcome of Assisted Reproductive Technologies.
.
Front Cell Dev Biol. 7:262.
2020
Hidalgo DM
,
Romarowski A
,
Gervasi MG
,
Navarrete F
,
Balbach M
,
Salicioni AM
,
Levin LR
,
Buck J
,
Visconti PE
. 2020.
Capacitation increases glucose consumption in murine sperm.
.
Mol Reprod Dev.
Wang X
,
Cai B
,
Yang X
,
Sonubi OO
,
Zheng Z
,
Ramakrishnan R
,
Shi H
,
Valenti L
,
Pajvani UB
,
Sandhu J
et al.
. 2020.
Cholesterol Stabilizes TAZ in Hepatocytes to Promote Experimental Non-alcoholic Steatohepatitis.
.
Cell Metab. 31(5):969-986.e7.
Balbach M
,
Gervasi MGracia
,
Hidalgo DMartin
,
Visconti PE
,
Levin LR
,
Buck J
. 2020.
Metabolic changes in mouse sperm during capacitation†.
.
Biol Reprod. 103(4):791-801.
Balbach M
,
Fushimi M
,
Huggins DJ
,
Steegborn C
,
Meinke PT
,
Levin LR
,
Buck J
. 2020.
Optimization of lead compounds into on-demand, nonhormonal contraceptives: leveraging a public-private drug discovery institute collaboration†.
.
Biol Reprod. 103(2):176-182.
Balbach M
,
Buck J
,
Levin LR
. 2020.
Using an Extracellular Flux Analyzer to Measure Changes in Glycolysis and Oxidative Phosphorylation during Mouse Sperm Capacitation.
.
J Vis Exp. (155)
2021
Rossetti T
,
Jackvony S
,
Buck J
,
Levin LR
. 2021.
Bicarbonate, carbon dioxide and pH sensing via mammalian bicarbonate-regulated soluble adenylyl cyclase.
.
Interface Focus. 11(2):20200034.
Fushimi M
,
Buck H
,
Balbach M
,
Gorovyy A
,
Ferreira J
,
Rossetti T
,
Kaur N
,
Levin LR
,
Buck J
,
Quast J
et al.
. 2021.
Discovery of TDI-10229: A Potent and Orally Bioavailable Inhibitor of Soluble Adenylyl Cyclase (sAC, ADCY10).
.
ACS Med Chem Lett. 12(8):1283-1287.
Balbach M
,
Ghanem L
,
Rossetti T
,
Kaur N
,
Ritagliati C
,
Ferreira J
,
Krapf D
,
Molina LCPuga
,
Santi CMaria
,
Hansen JNiklas
et al.
. 2021.
Soluble adenylyl cyclase inhibition prevents human sperm functions essential for fertilization.
.
Mol Hum Reprod. 27(9)
Chang J-C
,
Go S
,
Gilglioni EH
,
Duijst S
,
Panneman DM
,
Rodenburg RJ
,
Li HLam
,
Huang H-L
,
Levin LR
,
Buck J
et al.
. 2021.
Soluble adenylyl cyclase regulates the cytosolic NADH/NAD+ redox state and the bioenergetic switch between glycolysis and oxidative phosphorylation.
.
Biochim Biophys Acta Bioenerg. 1862(4):148367.
2022
Rossetti T
,
Ferreira J
,
Ghanem L
,
Buck H
,
Steegborn C
,
Myers RW
,
Meinke PT
,
Levin LR
,
Buck J
. 2022.
Assessing potency and binding kinetics of soluble adenylyl cyclase (sAC) inhibitors to maximize therapeutic potential.
.
Front Physiol. 13:1013845.
Miller M
,
Rossetti T
,
Ferreira J
,
Ghanem L
,
Balbach M
,
Kaur N
,
Levin LR
,
Buck J
,
Kehr M
,
Coquille S
et al.
. 2022.
Design, Synthesis, and Pharmacological Evaluation of Second-Generation Soluble Adenylyl Cyclase (sAC, ADCY10) Inhibitors with Slow Dissociation Rates.
.
J Med Chem. 65(22):15208-15226.
Ferreira J
,
Levin LR
,
Buck J
. 2022.
Strategies to safely target widely expressed soluble adenylyl cyclase for contraception.
.
Front Pharmacol. 13:953903.
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