Publications

Ramos-Espiritu L, Kleinboelting S, Navarrete FA, Alvau A, Visconti PE, Valsecchi F, Starkov A, Manfredi G, Buck H, Adura C et al..  2016.  Discovery of LRE1 as a specific and allosteric inhibitor of soluble adenylyl cyclase.. Nat Chem Biol. 12(10):838-44.

Ramos-Espiritu L, Diaz A, Nardin C, Saviola AJ, Shaw F, Plitt T, Yang X, Wolchok J, Pirog EC, Desman G et al..  2016.  The metabolic/pH sensor soluble adenylyl cyclase is a tumor suppressor protein.. Oncotarget. 7(29):45597-45607.

Rahman N, Ramos-Espiritu L, Milner TA, Buck J, Levin LR.  2016.  Soluble adenylyl cyclase is essential for proper lysosomal acidification.. J Gen Physiol. 148(4):325-39.

Navarrete FA, Alvau A, Lee HChang, Levin LR, Buck J, De Leon PMartin-, Santi CM, Krapf D, Mager J, Fissore RA et al..  2016.  Transient exposure to calcium ionophore enables in vitro fertilization in sterile mouse models.. Sci Rep. 6:33589.

Watson RL, Buck J, Levin LR, Winger RC, Wang J, Arase H, Muller WA.  2015.  Endothelial CD99 signals through soluble adenylyl cyclase and PKA to regulate leukocyte transendothelial migration.. J Exp Med. 212(7):1021-41.

Levin LR, Buck J.  2015.  Physiological roles of acid-base sensors.. Annu Rev Physiol. 77:347-62.

Kleinboelting S, Diaz A, Moniot S, van den Heuvel J, Weyand M, Levin LR, Buck J, Steegborn C.  2014.  Crystal structures of human soluble adenylyl cyclase reveal mechanisms of catalysis and of its activation through bicarbonate.. Proc Natl Acad Sci U S A. 111(10):3727-32.

Hess KC, Liu J, Manfredi G, Mühlschlegel FA, Buck J, Levin LR, Barrientos A.  2014.  A mitochondrial CO2-adenylyl cyclase-cAMP signalosome controls yeast normoxic cytochrome c oxidase activity.. FASEB J. 28(10):4369-80.

Shahidullah M, Mandal A, Wei G, Levin LR, Buck J, Delamere NA.  2014.  Nonpigmented ciliary epithelial cells respond to acetazolamide by a soluble adenylyl cyclase mechanism.. Invest Ophthalmol Vis Sci. 55(1):187-97.

Buck J, Levin LR.  2014.  The role of soluble adenylyl cyclase in health and disease.. Biochim Biophys Acta. 1842(12 Pt B):2533-4.

Chen X, Baumlin N, Buck J, Levin LR, Fregien N, Salathe M.  2014.  A soluble adenylyl cyclase form targets to axonemes and rescues beat regulation in soluble adenylyl cyclase knockout mice.. Am J Respir Cell Mol Biol. 51(6):750-60.

Martinez J, Stessin AM, Campana A, Hou J, Nikulina E, Buck J, Levin LR, Filbin MT.  2014.  Soluble adenylyl cyclase is necessary and sufficient to overcome the block of axonal growth by myelin-associated factors.. J Neurosci. 34(28):9281-9.

Valsecchi F, Ramos-Espiritu LS, Buck J, Levin LR, Manfredi G.  2013.  cAMP and mitochondria.. Physiology (Bethesda). 28(3):199-209.

Zippin JH, Chen Y, Straub SG, Hess KC, Diaz A, Lee D, Tso P, Holz GG, Sharp GWG, Levin LR et al..  2013.  CO2/HCO3(-)- and calcium-regulated soluble adenylyl cyclase as a physiological ATP sensor.. J Biol Chem. 288(46):33283-91.

Wertheimer E, Krapf D, de la Vega-Beltran JL, Sánchez-Cárdenas C, Navarrete F, Haddad D, Escoffier J, Salicioni AM, Levin LR, Buck J et al..  2013.  Compartmentalization of distinct cAMP signaling pathways in mammalian sperm.. J Biol Chem. 288(49):35307-20.

Chen J, Martinez J, Milner TA, Buck J, Levin LR.  2013.  Neuronal expression of soluble adenylyl cyclase in the mammalian brain.. Brain Res. 1518:1-8.

Rahman N, Buck J, Levin LR.  2013.  pH sensing via bicarbonate-regulated "soluble" adenylyl cyclase (sAC).. Front Physiol. 4:343.

Bitterman JL, Ramos-Espiritu L, Diaz A, Levin LR, Buck J.  2013.  Pharmacological distinction between soluble and transmembrane adenylyl cyclases.. J Pharmacol Exp Ther. 347(3):589-98.

Kolodecik TR, Shugrue CA, Thrower EC, Levin LR, Buck J, Gorelick FS.  2012.  Activation of soluble adenylyl cyclase protects against secretagogue stimulated zymogen activation in rat pancreaic acinar cells.. PLoS One. 7(7):e41320.

Salazar E, Bank EM, Ramsey N, Hess KC, Deitsch KW, Levin LR, Buck J.  2012.  Characterization of Plasmodium falciparum adenylyl cyclase-β and its role in erythrocytic stage parasites.. PLoS One. 7(6):e39769.

Topal H, Fulcher NB, Bitterman J, Salazar E, Buck J, Levin LR, Cann MJ, Wolfgang MC, Steegborn C.  2012.  Crystal structure and regulation mechanisms of the CyaB adenylyl cyclase from the human pathogen Pseudomonas aeruginosa.. J Mol Biol. 416(2):271-86.

Middelhaufe S, Leipelt M, Levin LR, Buck J, Steegborn C.  2012.  Identification of a haem domain in human soluble adenylate cyclase.. Biosci Rep. 32(5):491-9.

Choi HB, Gordon GRJ, Zhou N, Tai C, Rungta RL, Martinez J, Milner TA, Ryu JK, McLarnon JG, Tresguerres M et al..  2012.  Metabolic communication between astrocytes and neurons via bicarbonate-responsive soluble adenylyl cyclase.. Neuron. 75(6):1094-104.

Chen J, Levin LR, Buck J.  2012.  Role of soluble adenylyl cyclase in the heart.. Am J Physiol Heart Circ Physiol. 302(3):H538-43.

Schick J, Doerfler W.  1978.  Integration of adenovirus type 2 DNA in productively infected cells: results of sequential hybridization experiments.. J Gen Virol. 39(2):365-70.