Publications

Luque GM, Jabloñski M, Schiavi-Ehrenhaus LJ, Del Prado RC, Balbach M, Romarowski A, Martin-Hidalgo D, Visconti PE, Krapf D, Darszon A et al..  2025.  Bovine serum albumin-induced calcium influx triggers soluble adenylyl cyclase activation and cyclic AMP signalling pathways in mouse sperm capacitation.. J Physiol. 603(9):2633-2653.

Levin LR, Buck J.  2015.  Physiological roles of acid-base sensors.. Annu Rev Physiol. 77:347-62.

Kolodecik TR, Shugrue CA, Thrower EC, Levin LR, Buck J, Gorelick FS.  2012.  Activation of soluble adenylyl cyclase protects against secretagogue stimulated zymogen activation in rat pancreaic acinar cells.. PLoS One. 7(7):e41320.

Kleinboelting S, Ramos-Espiritu L, Buck H, Colis L, van den Heuvel J, J Glickman F, Levin LR, Buck J, Steegborn C.  2016.  Bithionol Potently Inhibits Human Soluble Adenylyl Cyclase through Binding to the Allosteric Activator Site.. J Biol Chem. 291(18):9776-84.

Kleinboelting S, Diaz A, Moniot S, van den Heuvel J, Weyand M, Levin LR, Buck J, Steegborn C.  2014.  Crystal structures of human soluble adenylyl cyclase reveal mechanisms of catalysis and of its activation through bicarbonate.. Proc Natl Acad Sci U S A. 111(10):3727-32.

Hidalgo DM, Romarowski A, Gervasi MG, Navarrete F, Balbach M, Salicioni AM, Levin LR, Buck J, Visconti PE.  2020.  Capacitation increases glucose consumption in murine sperm.. Mol Reprod Dev.

Hess KC, Liu J, Manfredi G, Mühlschlegel FA, Buck J, Levin LR, Barrientos A.  2014.  A mitochondrial CO2-adenylyl cyclase-cAMP signalosome controls yeast normoxic cytochrome c oxidase activity.. FASEB J. 28(10):4369-80.

Gardner ER, Kopf GS, Buck J, Levin LR.  2026.  Targeting Soluble Adenylyl Cyclase for On-Demand Contraception.. Physiology (Bethesda). 41(5)

Gandhi JK, Chowdhury URoy, Manzar Z, Buck J, Levin LR, Fautsch MP, Marmorstein AD.  2017.  Differential Intraocular Pressure Measurements by Tonometry and Direct Cannulation After Treatment with Soluble Adenylyl Cyclase Inhibitors.. J Ocul Pharmacol Ther. 33(8):574-581.

Fushimi M, Buck H, Balbach M, Gorovyy A, Ferreira J, Rossetti T, Kaur N, Levin LR, Buck J, Quast J et al..  2021.  Discovery of TDI-10229: A Potent and Orally Bioavailable Inhibitor of Soluble Adenylyl Cyclase (sAC, ADCY10).. ACS Med Chem Lett. 12(8):1283-1287.

Fischoeder J, Marathe JG, Anderson DJ, Levin LR, Buck J, Ritagliati C.  2026.  Assessing efficacy of ADCY10 inhibitors in cervical mucus.. Mol Hum Reprod.

Ferreira J, Belliveau H, Levin LR, Buck J.  2025.  Biochemical characterization of the full-length isoform of soluble adenylyl cyclase.. J Biol Chem. 301(12):110889.

Ferreira J, Levin LR, Buck J.  2022.  Strategies to safely target widely expressed soluble adenylyl cyclase for contraception.. Front Pharmacol. 13:953903.

Choi HB, Gordon GRJ, Zhou N, Tai C, Rungta RL, Martinez J, Milner TA, Ryu JK, McLarnon JG, Tresguerres M et al..  2012.  Metabolic communication between astrocytes and neurons via bicarbonate-responsive soluble adenylyl cyclase.. Neuron. 75(6):1094-104.

Chen J, Martinez J, Milner TA, Buck J, Levin LR.  2013.  Neuronal expression of soluble adenylyl cyclase in the mammalian brain.. Brain Res. 1518:1-8.

Chen J, Levin LR, Buck J.  2012.  Role of soluble adenylyl cyclase in the heart.. Am J Physiol Heart Circ Physiol. 302(3):H538-43.

Chen X, Baumlin N, Buck J, Levin LR, Fregien N, Salathe M.  2014.  A soluble adenylyl cyclase form targets to axonemes and rescues beat regulation in soluble adenylyl cyclase knockout mice.. Am J Respir Cell Mol Biol. 51(6):750-60.

Chang J-C, Go S, Gilglioni EH, Duijst S, Panneman DM, Rodenburg RJ, Li HLam, Huang H-L, Levin LR, Buck J et al..  2021.  Soluble adenylyl cyclase regulates the cytosolic NADH/NAD+ redox state and the bioenergetic switch between glycolysis and oxidative phosphorylation.. Biochim Biophys Acta Bioenerg. 1862(4):148367.

Buck J, Levin LR.  2014.  The role of soluble adenylyl cyclase in health and disease.. Biochim Biophys Acta. 1842(12 Pt B):2533-4.

Bitterman JL, Ramos-Espiritu L, Diaz A, Levin LR, Buck J.  2013.  Pharmacological distinction between soluble and transmembrane adenylyl cyclases.. J Pharmacol Exp Ther. 347(3):589-98.

Balbach M, Fushimi M, Huggins DJ, Steegborn C, Meinke PT, Levin LR, Buck J.  2020.  Optimization of lead compounds into on-demand, nonhormonal contraceptives: leveraging a public-private drug discovery institute collaboration†.. Biol Reprod. 103(2):176-182.

Balbach M, Gervasi MGracia, Hidalgo DMartin, Visconti PE, Levin LR, Buck J.  2020.  Metabolic changes in mouse sperm during capacitation†.. Biol Reprod. 103(4):791-801.

Balbach M, Ghanem L, Rossetti T, Kaur N, Ritagliati C, Ferreira J, Krapf D, Molina LCPuga, Santi CMaria, Hansen JNiklas et al..  2021.  Soluble adenylyl cyclase inhibition prevents human sperm functions essential for fertilization.. Mol Hum Reprod. 27(9)

Balbach M, Buck J, Levin LR.  2020.  Using an Extracellular Flux Analyzer to Measure Changes in Glycolysis and Oxidative Phosphorylation during Mouse Sperm Capacitation.. J Vis Exp. (155)

Ayoub S, Sanchez NDel RRive, Fischoeder J, Balbach M, Levin LR, Buck J, Ritagliati C.  2025.  Cyclic AMP Rescue of Motility in Sperm Devoid of Soluble Adenylyl Cyclase.. Int J Mol Sci. 26(4)